Use of MRI in the Neurologic Patient

by Ronald Lyman, DVM, DACVIM and Beatrix Nanai, DVM

from DVM Newsmagazine.

In contemporary veterinary medicine, magnetic resonance imaging (MRI) is an important tool in the diagnosis of neurological problems.

However, MRI does not simply display the diagnosis. Other diagnostic tests, such as survey radiographs, myelogram, serologies, cerebrospinal fluid analysis, electro-encephalography and histopathology still remain crucial in the thought process toward the definitive diagnosis.

In a recent article, 76 percent of the dogs with inflammatory cerebrospinal fluid (CSF) had detectable MR brain lesions, while 24 percent did not (C.R. Lamb et al.: Magnetic Resonance Imaging Findings in 25 Dogs with Inflammatory Cerebrospinal Fluid, Vet Radiol Ultrasound, Vol. 46, No. 1, 2005, pp 17-22). Two out of the 25 dogs with inflammatory CSF had a focal lesion, and one of these patients had neoplasia (choroid plexus papilloma). Seventeen had multifocal or diffuse lesions throughout the brain. The definitive and the tentative diagnoses for these patients included granulomatous meningoencephalitis, toxoplasmosis, neosporosis, distemper, non-specific meningitis, necrotizing fasciitis and pug encephalitis. Six dogs out of 25 had no lesions visible on MRI.

mri_articlePhoto 1 A (left), B: T2 (A) and post-gadolinium T1 (B) images of a 9-year-old Poodle with cervical pain. Hydrocephalus found on magnetic resonance (MR) imaging, but no other detectable MR lesions. Interestingly, the CSF was inflammatory. The patient’s signs resolved on prednisolone/cyclosporine therapy.

Some structural brain abnormalities are common features of different disease processes, and 28 percent of the dogs with inflammatory CSF in the article showed a mass effect on MRI. Mass effects are not exclusively associated with brain tumors. They can be a feature of several other conditions, such as vascular disease (G.B. Cherubini et al: Utility of Magnetic Resonance Imaging for Distinguishing Neoplastic from Non-neoplastic Brain Lesions in Dogs and Cats, Vet Radiol Ultrasound, Vol. 46, No. 5, 2005, pp 384-387) or some of the previously mentioned inflammatory diseases. Hydrocephalus is another non-specific finding of different intracranial lesions. In addition to the congenital form found primarily in brachiocephalic breeds, hydrocephalus was found in some dogs with inflammatory diseases in the first article and in 39 percent of the neoplastic and 31 percent of the non-neoplastic conditions in the second article (Photo 1).

In general, the inflammatory lesions appeared hypointense on T1 and hyperintense on T2 sequences. The use of gadolinium contrast material increased the sensitivity of MRI with inflammatory lesions in the first article and had a predictive value of 74 percent for neoplasia in the second article.

Follow-up MRI studies are not often performed in veterinary medicine because of the expense and the owners’ concerns regarding the anesthesia. It would be of diagnostic value to perform follow-up MRI examinations after certain treatments, tracking the size, intensity and enhancement of the lesion(s).

As a summary, MRI is important but not the only diagnostic procedure that should be performed in a patient with intracranial disease. It is important for the clinician to explain to the owner the significance of other neurological diagnostic tests and the limitations of the MRI.

© RKLyman, LLC. All Rights Reserved.

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